Sugar, MSG & Neuro-degenerative disorders...

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Sugar, MSG & Neuro-degenerative disorders...

Postby misterjuanperalta on July 28th, 2015, 5:09 pm

While MSG and aspartame (excito-toxins) are probably not causes of the neuro-degenerative diseases, such as Alzheimer’s dementia and Parkinson’s disease, they may precipitate these disorders and certainly worsen their effects.... Dr. Blaylock believes that avoidance of these excito-toxins and supplementation of Magnesium, Taurine, Vitamin B and CoQ10 might prove beneficial.

Regarding supplements, it has been shown that when neurons involved in Parkinson’s and Huntington’s diseases are exposed to micro-injected excito-toxins there is a dramatic and rapid fall in energy production by these neurons. CoQ10 has been shown to restore energy production, but not to prevent cellular death. But when combined with niacin-amide, both cellular energy production and neuron protection is seen. I would recommend a combination of CoQ10, acetyl-L carnitine, niacin-amide, riboflavin, methylcobalamin, and thiamine to treat neurological symptoms.

One of the newer revelations of modern molecular biology is the discovery of mitochondrial diseases, where cellular energy deficiency is a hallmark. In many of these disorders a significant clinical improvement has been seen following a similar regimen of vitamins combined with CoQ10 and L-carnitine. Acetyl L-carnitine enters the brain in higher concentrations and also increases brain acetylcholine, necessary for normal memory function. While these particular substances have been found to significantly boost brain energy function, they are not alone in this important property.

Phosphotidyl serine, Ginkgo Biloba, vitamin B12, folate, magnesium, Vitamin K and several others are also being shown to be important. While mitochondrial dysfunction is important in explaining why some are more vulnerable to excito-toxin damage than others, it does not explain injury in those with normal cellular metabolism. There are several conditions under which energy metabolism is impaired. For example, approximately one third of Americans suffer from what is known as reactive hypoglycemia, where the blood glucose reading less than 72. That is, they respond to a meal composed of either simple sugars or carbohydrates that are quickly broken down into simple sugars (high in the glycemic index) by secreting excessive amounts of insulin. This causes a dramatic lowering of the blood sugar.

When the blood sugar falls, the body responds by releasing a burst of epinephrine from the adrenal glands to raise the blood sugar. We feel this release as nervousness, palpitations of our heart, tremulousness and profuse sweating. Occasionally, one can have a slower fall in the blood sugar that will not produce a reactive release of epinephrine, thereby producing few symptoms. This can be more dangerous because we are unaware that our glucose reserve is falling until we develop obvious neurological symptoms, such as difficulty thinking and a sensation of lightheadedness.

The brain is one of the most glucose dependent organs known because it has a limited ability to burn other substrates such as fats. There is some evidence that several of the neuro-degenerative diseases are related to either excessive insulin release, as with Alzheimer’s disease, or impaired glucose utilization, as we have seen in the case of Parkinson’s disease and Huntington’s disease.

It is my firm belief, based on clinical experience and physiological principles, that many of these diseases occur primarily in the face of either reactive hypoglycemia or brain hypoglycemia. In at least two well conducted studies, it was found that pure Alzheimer’s dementia was rare in those with normal blood sugar profiles. Whereas in most cases Alzheimer’s patients had low blood sugars and high CSF (cerebrospinal fluid) insulin levels. In my own limited experience with Parkinson’s patients, for example, I have found a disproportionately high number suffering from reactive hypoglycemia.

I found it interesting that several patients with neuro-degenerative diseases have observed an association between their symptoms and gluten. That is, when they adhere to a gluten free diet they improve clinically. It may be that by avoiding gluten-containing products, such as bread, crackers, cereal, pasta, etc., they are also avoiding products that are high on the glycemic index, which produce reactive hypoglycemia. Also, all of these food items are high in free iron. Clinically, hypoglycemia will worsen the symptoms of most neurological disorders. We know that severe hypoglycemia can mimic MND both clinically and pathologically. It is also known that many of the symptoms of Alzheimer’s disease resemble hypoglycemia, as if the brain were hypoglycemic in isolation.

Source: http://www.russellblaylockmd.com/
Source: viewtopic.php?f=5&t=13069&p=91928&hilit=alzheimer%27s#p91928

Important to note:

Dr. John Hayes Jr. emphasizes to PLEASE CUT THE CARBOHYDRATES DOWN TO 20g PER MEAL. READ ALL LABELS AND CHECK SERVING SIZE. CARBS, PLAIN AND SIMPLE. These foods can create higher than normal blood sugars, especially over time. High blood sugars and excess insulin or insulin insensitivity of the body over time create metabolic syndrome or eventually diabetes. These conditions set the stage for inflammation, oxygen deprivation of cells and glycosilation (sugar attachment if you will) of body proteins. Dr. Terry Wahls told me to use no more than 1 tsp of sugar per day, in coffee.

Also, use artificial sweeteners at your own risk (keeping in mind its effect on metabolism or insulin secretion). Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.

Source: http://www.ncbi.nlm.nih.gov/pubmed/25231862
Source: http://www.ncbi.nlm.nih.gov/pubmed/20303371
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900484/

Some reported side effects of certain artificial sweeteners include blurred vision, gastrointestinal problems, neuro-degenerative disorders, weight gain and poor sugar metabolism.

Source: http://www.earthclinic.com/cures/side-e ... eners.html

There is a new Biomarker for Type 2 Diabetes, where lower amounts of mitochondrial DNA with a higher amount of methylation were observed from the blood samples. It's indicated that mitochondrion is responsible for converting chemical energy from food into energy that cells can use.

Source: http://www.doctorpulse.co/?p=5195

One test your doctor isn’t doing that could save your life is the 2-Hour Insulin Glucose Challenge Test. Your blood sugar levels should be less than 80 mg/dl fasting and never rise above 110 or 120 mg/dl after one and two hour checks. Your insulin should be less than 5 mg/dl fasting and should never rise above 30 mg/dl after one and two hour checks.

Source: http://drhyman.com/blog/2014/08/18/one- ... save-life/

Hypoglycemia (or hyperinsulinemia) plays an adverse role in the nervous system, and results in the paucity of alternative fuel used by the brain.

... Common conditions that cause excessive glutamate concentrations around neurons are hypoglycemia. Blood sugars are the primary glutamate removal method from inter-synaptic spaces at the NMDA and AMPA receptor site.

Source: https://en.wikipedia.org/wiki/Excitotoxicity
Source: http://www.news-medical.net/health/Hype ... ments.aspx
Source: http://emedicine.medscape.com/article/921258-treatment

Hypoglycemia (and/or metabolic neuropathies) can cause muscle cramps and twitching.

As hypoglycemia progresses, a variety of symptoms can occur, including muscle twitching. Amongst 300 patients in one study (185 female, 115 male) found to have relative/reactive hypoglycemia (a drop of 20% or more below the fasting blood sugar level during a 6-hour glucose tolerance test), 23% had muscular twitching or cramps.

Source: http://www.diagnose-me.com/symptoms-of/ ... ching.html
Source: https://en.wikipedia.org/wiki/Reactive_hypoglycemia
Source: http://www.nlm.nih.gov/medlineplus/ency ... 001161.htm

Hypoglycaemia, common in diabetic patients treated with insulin, can induce various neurological disturbances. Of these, seizures are the most common acute symptom, mainly of the generalized tonic-clonic type, with focal events only exceptionally being reported and documented. Hypoglycaemia can modify cortical excitability by determining an imbalance between excitation and inhibition; some brain structures, such as the temporal lobe and hippocampus, appear to be particularly susceptible to this insult. We describe a case of a 61-year-old diabetic patient in whom insulin-induced transient hypoglycaemia triggered a focal seizure of temporal origin that was well documented by EEG during 24-hour ambulatory monitoring. This is, to our knowledge, one of the few, well-documented cases of this type of seizure.

Source: http://www.ncbi.nlm.nih.gov/pubmed/20159673
Source: Source (tongue biting): http://www.ncbi.nlm.nih.gov/pubmed/7487261

Dr. John Hayes Jr. states that GTT + fasting insulin tests are key for a BFS and reactive hypoglycemia diagnosis.

Source: http://www.beatingneuropathy.com/about-dr-john-hayes-jr

High glucose (hyperglycemia) induces mitochondrial dysfunction with adverse neurological effects.

Source: http://www.ncbi.nlm.nih.gov/pubmed/22399425
Source: http://www.sott.net/article/301296-Thre ... l-function

Muscle cramping is a relatively common manifestation of Diabetes Mellitus (DM). It can be the result of electrolyte imbalances, hypoglycemia, peripheral vascular disease with arterial insufficiency, and/or peripheral neuropathies. The cramps tend to be more common in the lower extremities and may be seen more commonly at night. Symptoms include cramping muscle pain and, at times, fasciculations secondary to lower motor neuron lesions. These cramps may be confused with hypocalcemic cramps and the Restless Legs Syndrome.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839979/

Alpha Lipoic Acid (600mg/day) and SOD (at least 140 IU/day) is useful in regulating sugar, restoring antioxidants in the brain, treating neuropathies, certain spinal cord injuries and other diseases. Several articles linked below demonstrate this.

Source: http://www.ncbi.nlm.nih.gov/pubmed/9285502
Source: http://www.ncbi.nlm.nih.gov/pubmed/20421656
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836194/
Source: http://www.ncbi.nlm.nih.gov/pubmed/15529636
Source (Alzheimer's): http://www.ncbi.nlm.nih.gov/pubmed/17982894
Source (Alzheimer's): http://www.ncbi.nlm.nih.gov/pubmed/18655815
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272801/
Source: http://www.ncbi.nlm.nih.gov/pubmed/17065669
Source (Multiple Sclerosis): http://www.ncbi.nlm.nih.gov/pubmed/22917609
Source (SOD/ALA, Low back pain): http://www.ncbi.nlm.nih.gov/pubmed/23860422
Source (SOD, Alzheimer's): http://www.ncbi.nlm.nih.gov/pubmed/22072713
Source (SOD/ALA, Neuropathy): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586118/
Source: (ALA, Parkinson's): http://www.ncbi.nlm.nih.gov/pubmed/26084861
Source (R-ALA, Brain): http://www.ncbi.nlm.nih.gov/pubmed/15829111

Curcumin (Turmeric) is excellent for liver health, provides anti-inflammatory benefits, can be used to help treat peripheral neuropathy and epileptic seizures.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526841/
Source: http://healthclover.com/turmeric-peripheral-neuropathy/

Dietary approaches and other treatments may be more appropriate depending on the age of the individual and the type of epilepsy. A high-fat, very low carbohydrate ketogenic diet is often used to treat medication-resistant epilepsies. The diet induces a state known as ketosis, which means that the body shifts to breaking down fats instead of carbohydrates to survive. A ketogenic diet effectively reduces seizures for some people, especially children with certain forms of epilepsy. Studies have shown that more than 50 percent of people who try the ketogenic diet have a greater than 50 percent improvement in seizure control and 10 percent experience seizure freedom. Some children are able to discontinue the ketogenic diet after several years and remain seizure-free, but this is done with strict supervision and monitoring by a physician. Curcumin (Turmeric) helps reduce seizures.

Source: http://www.ninds.nih.gov/disorders/epil ... ilepsy.htm
Source: http://www.ncbi.nlm.nih.gov/pubmed/20840851

Alpha-Ketoglutarate (AKG) is a biological substance that plays important roles in cell metabolism and physiology. It has also been used to treat or improve MND and its symptoms. Notice how sugar is a common denominator.

Source: http://www.ncbi.nlm.nih.gov/pubmed/25061944
Source: http://www.ncbi.nlm.nih.gov/pubmed/26122777

Now, could Phosphatidylserine help our BFS? You decide ...

A large body of scientific evidence describes the interactions among PS, cognitive activity, cognitive aging, and retention of cognitive functioning ability. Phosphatidylserine is required for healthy nerve cell membranes and myelin. Aging of the human brain is associated with biochemical alterations and structural deterioration that impair neurotransmission. Exogenous PS (300-800 mg/d) is absorbed efficiently in humans, crosses the blood-brain barrier, and safely slows, halts, or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions, including the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories, the ability to retrieve memories, the ability to learn and recall information, the ability to focus attention and concentrate, the ability to reason and solve problems, language skills, and the ability to communicate. It also supports locomotor functions, especially rapid reactions and reflexes.

Source: http://www.ncbi.nlm.nih.gov/pubmed/25933483
Source: http://www.holistichealthliving.com/201 ... pplements/

Further, we’re all familiar with tension and the inability to think clearly that occurs during stressful situations. However, did you know that they may be symptoms of imbalanced cortisol levels that result from too much stress and anxiety? Adrenal fatigue syndrome occurs when adrenal glands don’t function properly, usually due to prolonged environmental, physical, or emotional stress. It’s no surprise that those situations trigger the release of the “stress-hormone,” cortisol. Elevated cortisol levels can even result from heavy exertion during strenuous exercise or from just having a lot on your plate in life. There’s good news though. The wonder-kid of cognitive enhancing nutrients, PS, protects you from stress by reducing cortisol levels during taxing times, which can be a real lifesaver!

Source: https://www.getoptimind.com/phosphatidy ... nge-lives/
Last edited by misterjuanperalta on January 7th, 2016, 8:35 am, edited 91 times in total.
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby mwagner on July 31st, 2015, 2:40 pm

This is really interesting to me, as I have suffered from reactive hypoglycemia since I was in my mid-twenties. Anyone else?

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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby leaflea on August 1st, 2015, 12:37 am

I don't know if I'm hypoglycemic but likely have highs and crashes since I'm a sugar addict. I'm on the wagon as of NOW August 1, 2015. No more candy for me
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby misterjuanperalta on August 1st, 2015, 6:20 am

Make sure to note the Alpha Lipoic Acid portion of this post and listed sources. It's good to make positive changes.
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby Bibi on August 8th, 2015, 5:00 pm

leaflea wrote:I don't know if I'm hypoglycemic but likely have highs and crashes since I'm a sugar addict. I'm on the wagon as of NOW August 1, 2015. No more candy for me


Same here ! I have gained 7 kg since i started Mirtazapine and have heartburn so one week ago i decided to Cut off ,chocolat , candy and cookies. But i am a bit confused after Reading , is sugar neuroprotective or ?..
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby misterjuanperalta on August 8th, 2015, 8:06 pm

Sugar is protective in the right amounts and when balanced. It aids in glutamate processing / removal, as aforementioned. I'm thinking poor sugar metabolism is directly related to neurological diseases. Example is listed below.

Alzheimer's Disease Is Type 3 Diabetes – Evidence Reviewed: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby Xina535 on August 11th, 2015, 6:12 am

I didn't see this topic before, so thanks for posting the link in the other thread, misterjuan.

I do eat lots of sugar things - like breads, peanut butter, chocolate, jelly, pasta, cereal, etc. If I went on a gluten free, sugar free diet, and supplemented with

Alpha Lipoic Acid (600mg a day)
CoQ10
acetyl-L carnitine
niacin-amide
riboflavin
methylcobalamin
thiamine
Phosphotidyl serine
Ginkgo Biloba
vitamin B12
folate
magnesium
Vitamin K

and I feel better, then maybe my symptoms are due to my metabolism? And, how much of each would I need to take (I know 600 mg for the ala).
How would it interfere with my psycho meds, or would it at all?
How long should I be on this diet to give it a real chance to work/change?
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby Xina535 on August 11th, 2015, 9:18 am

oh and another question - are we talking eliminating only processed sugars, or also natural sugars/sweets (fruit, honey, agave, etc)?
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby Xina535 on August 15th, 2015, 2:55 pm

Ok - Day 1 - no gluten, no sugar, low carb and vegetarian diet (I am actually vegan, but for this diet I decided to include eggs from the chickens at the farm up the road from us)

Breakfast 1 hard boiled egg
Snack some almonds, walnuts, hazelnuts
Lunch homemade hummus, a few carrot sticks, 1 red pepper
Snack fresh green beans
Dinner lightly pan fried broccoli and 2 hard boiled eggs

other meals on my list for this week are
homemade bean/ground soy chili
tofu scramble with onions and peas
zucchinni/green onion frittata (just no cheese) - http://www.joyoushealth.com/blog/2013/0 ... ps-recipe/
homemade salsa with refried beans
salad with sugar-free balsamic vinegar and olive oil
homemade vegetable soup - I found sugar and gluten free vegetable broth

no fruits (only a little lemon in the hummus)

to drink - only water

and this multi-vitamin (so far, still looking for more supplements):
100% daily value:
A (800 ug RE), B1 (1.1mg), B2 (1.4mg), B6 (1.4mg), B12 (2.5ug), C (80mg), D3 (5ug), E (12mg a-TE), K1 (75ug), Biotin (B7? - 50ug), Chrome (40ug), Fluor (3.5mg), Folic acid (200ug), Iodine (150ug), Iron (14mg), Niacin (B3? - 16mg NE), Pantothenic acid (B5? - 6mg), Copper (1000ug), Manganese (2mg), Molybdenum (50ug), Selenium (55ug), Zinc (10mg)
15% daily value:
Calcium (120mg), Magnesium (56mg)
Other:
Ginkgo biloba extract - 50mg
Lutein - 500ug

so I am going to try to stick to this as long as I can! I am also open to any tips, advice, thoughts....!

Question if anyone knows - I bought tahini for the hummus and I am just now seeing that not all tahini may be gluten free! :?: I am reading mixed information online. The tahini I bought says as ingredients "100% sesame seeds."
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby misterjuanperalta on August 15th, 2015, 3:59 pm

Excellent. Only sugar I use is Stevia extract, small doses. Primary ingredient must be Stevia and almost no other ingredients.
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Re: Sugar, MSG & Neuro-degenerative disorders...

Postby leroyb on August 15th, 2015, 4:05 pm

That's an excellent list of supplements Xina. I post a good bit on ALSTDI forums and everything you take is recommended so if on the very very very slight chance you have something neurological going on you are taking all the right things.

My only comment would be CoQ10 has very poor bio availability so you'd need to take a lot of it for it to make any difference unless you want to pay for something like Mito-Q which ain't cheap.
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Re: Sugar, MSG & Neuro-degenerative disorders...

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