Potassium / Sodium Channel /Excitability /Retigabine

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Potassium / Sodium Channel /Excitability /Retigabine

Postby jamber on May 11th, 2011, 11:04 am

Good article......Retigabine reduces the excitability of unmyelinated peripheral human axons
http://ucl.ac.uk/npp/npp/dab/Lang.PM_et ... rticle.pdf

I write the main conclusions. Did you talk with your expert neurologist in BFS about retigabine?

1) inhibition of action potentials by blockade
of voltage-dependent sodium channels has been successful in some
clinical neuropathic pain conditions (for review see Priestley and
Hunter, 2006).
Potassium channels, too, contribute to the excitability of nociceptive
neurons. The importance of Kþ conductances for the development
of spontaneous and ectopic action potential generation
has been documented by experimental findings.

2) the findings of this study do support the view that
retigabine may become a possible option in the treatment of neuropathic
pain (Blackburn-Munro and Jensen, 2003; Passmore et al.,
2003; Dost et al., 2004; Blackburn-Munro et al., 2005; Surti and Jan,
2005). The reduction in excitability of peripheral C-type nerve
fibers may help not only to suppress the development of spontaneous,
ectopic action potential generation but also to suppress
stimulus-dependent symptoms such as allodynia and/or hyperalgesia.
Recently, the inhibition of ectopic activity has been demonstrated
in axotomized sensory fibers (Roza and Lopez-Garcia, in
press). Reduction of stimulus-dependent symptoms may be caused
by the retigabine-mediated attenuation in the ability to produce
bursts of action potentials.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby chicagobfs on May 19th, 2011, 10:49 am

This drug is not available in USA:/ Thus no point to ask :cry:
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby tiggida on May 19th, 2011, 1:59 pm

Chicago,
That bites man! Do you know why it isn't available here?
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby msm on May 19th, 2011, 11:29 pm

Yes, the FDA approved it but than decided not to pass it until glakso and valient submitted some papers that had nothing to do with clinical use or safety of the drug but rather tie up some loose questions they had regarding it. It was supposedley more of a paperwork thing. The papers were submitted in February and there is still no word on whether they will pass it here or not.

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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby trajon_34 on August 5th, 2011, 2:21 pm

I'm not a drug expert or FDA approval expert but didn't this get approved in June 2011? Anybody on this? See below:

http://en.wikipedia.org/wiki/Retigabine

Retigabine (INN) or ezogabine (USAN), codenamed D-23129, is an anticonvulsant used as a treatment for partial epilepsies. The drug was developed by Valeant Pharmaceuticals and GlaxoSmithKline. It was approved by the European Medicines Agency under the trade name Trobalt on March 28, 2011, and by the United States Food and Drug Administration (FDA), under the trade name Potiga, on June 10, 2011.
Retigabine works primarily as a potassium channel opener—that is, by activating a certain family of voltage-gated potassium channels in the brain.[2][3][4] This mechanism of action is unique among antiepileptic drugs, and may hold promise for the treatment of other neurologic conditions, including migraine and neuropathic pain.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby chicagobfs on August 5th, 2011, 4:05 pm

So who's first to try?? :) I will ask my doctor why he thinks
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby trajon_34 on August 5th, 2011, 5:25 pm

chicagobfs wrote:So who's first to try?? :) I will ask my doctor why he thinks



I plan on asking too. I have appointment in mid August.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby tiggida on August 5th, 2011, 7:03 pm

keep us updated, i hope it works, i would like to try too, but am currently breastfeeding.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby garym on August 6th, 2011, 1:16 am

I believe that ka/na channels are the key to our condition. If there is a way to correct imbalances at the cellular level, I think we could cure bfs....my $.02.

Take care,
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby trajon_34 on August 6th, 2011, 3:08 am

garym wrote:I believe that ka/na channels are the key to our condition. If there is a way to correct imbalances at the cellular level, I think we could cure bfs....my $.02.

Take care,
Gary



From my very limited knowledge/experience and conversations with my neurologist, I'd agree with this.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby dreadpirateroberts on August 9th, 2011, 8:30 am

I tend to agree too. And I hope it works. However, even though it may have been approved, it may take a while longer to see it on health plan prescription lists. And even then there will be no generic for it for years. So it will be interesting to see what the cost is here in the U.S. I'm sure it will be very pricey. Has anyone looked into the cost? I searched for it and found a couple of European articles which show it would be about $800 per year, but I don't know if that is with or without health insurance/coverage reductions.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby nonstop on August 16th, 2011, 6:01 pm

I got my doctor to prescribe it but the pharmacy doesn't show it on record (I'm in US). Maybe because it's so new? I have seen it advertised on Canadian med sites. Maybe I will have to order through them?
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby trajon_34 on August 16th, 2011, 7:10 pm

nonstop wrote:I got my doctor to prescribe it but the pharmacy doesn't show it on record (I'm in US). Maybe because it's so new? I have seen it advertised on Canadian med sites. Maybe I will have to order through them?



Interesting. Thanks for the update on this. I think someone mentiond in another thread that it might not be avialable (although approved) until later this year. I'm fairly clueless to how all of this works.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby TwitchyDoc on August 17th, 2011, 1:31 am

Well, do not want to be party breaker, but it says "unmyelinated". With BFS there is no loss of myelin, that is typical for MS.
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Re: Potassium / Sodium Channel /Excitability /Retigabine

Postby nonstop on August 20th, 2011, 8:40 pm

TwitchyDoc wrote:Well, do not want to be party breaker, but it says "unmyelinated". With BFS there is no loss of myelin, that is typical for MS.


Your statement doesn't preclude us from trying this medication. We will make the decision on whether it helps or not and will report back. :)
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Re: Potassium / Sodium Channel /Excitability /Retigabine

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