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How OTC Deficiency compares to Ammonia-induced ALS

PostPosted: December 27th, 2017, 8:25 pm
by misterjuanperalta
Aggravants / Precursors to OTC Deficiency -

Fructose - Fructose consumption leads to the accumulation of fructose-1-phosphate in cells, which may partially deplete intracellular ATP levels in susceptible individuals. Decreased cellular ATP causes disturbances in protein synthesis and reduced ammonia detoxification. Side-effects include fatigue, headaches, dizziness, behavioral changes and depressed immune function (autoimmunity, allergies).

Source: http://www.drkaslow.com/html/fructose.html

Low stomach acid - Low stomach acid impairs the proper digestion of foods, including protein, and elevates ammonia levels. Treatment could include ingesting vinegar before and after meals. Because vinegar is an acid and ammonia is a base, ingesting it neutralizes and detoxifies ammonia, producing salt and water as a byproduct. In fact, Lactulose, used to treat hyperammonemia, is metabolized in the colon to form short-chain fatty acids, including lactic acid and acetic acid. Acetic acid makes up about 5–6% of apple cider vinegar.

Source: http://www.wakingtimes.com/2015/04/16/p ... dic-foods/, https://en.wikipedia.org/wiki/Lactulose, https://articles.mercola.com/sites/arti ... -hype.aspx

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OTC Deficiency:

• Seizures, abnormal motor functions and dysarthria

https://www.ncbi.nlm.nih.gov/pubmed/25687292

• Episodes of hyperammonemia secondary to increased protein intake.

https://emedicine.medscape.com/article/ ... -treatment

• Emphasis on low protein diet

https://www.ncbi.nlm.nih.gov/pubmed/25949836

• Elevated ornithine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342550/

• Decreased citrulline

https://www.ncbi.nlm.nih.gov/pubmed/25932215

• Plasma citrulline depletion is greater than that of plasma arginine.

https://ojrd.biomedcentral.com/articles ... 015-0266-1

• Decreased arginine

https://www.ncbi.nlm.nih.gov/pubmed/28597413

• Elevated glutamine

https://www.ncbi.nlm.nih.gov/pubmed/28266016
https://www.ncbi.nlm.nih.gov/pubmed/25958381

• Elevated glutamine-to-citrulline ratio

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316440/
https://www.ncbi.nlm.nih.gov/pubmed/25958381

• Elevated orotic acid

https://www.ncbi.nlm.nih.gov/pubmed/29123827

• Decreased BUN

https://en.wikipedia.org/wiki/Orotic_aciduria

• Genetic testing: https://www.invitae.com/en/physician/te ... =CAT000056

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Ammonia-induced ALS:

• Increased ammonia production from dietary sources (protein) can cause chronic hyperammonemia (>35–50 µM) and consequent neurodegeneration and motor impairments.

• Intense or prolonged physical exertion, an ammoniogenic activity, is an ALS risk factor that explains the sudden onset of symptoms.

• Decreased arginine levels, an amino acid required for liver urea cycle function, has been found in ALS patients.

• Increased glutamine, a precursor of ammonia, has been found in familial ALS.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063041/