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BFS as a Manifestation of Small Fiber Neuropathy

PostPosted: August 9th, 2015, 7:55 pm
by misterjuanperalta
Benign Fasciculation Syndrome (BFS) is characterized by widespread involuntary muscle activity consisting of muscle twitching or fasciculations. The cause is unknown and no anatomical or physiologic lesions have been identified to date. In 4 of the 14 patients (36%), the ENFD was significantly decreased in the calf, and normal at the thigh, and in 10 the ENFD was normal at both biopsy sites. Six of 11 patients tested (54%), had significantly decreased SGNFD; 2 at both the calf and thigh, 2 at the calf only, 1 at the thigh only, and 1 at the foot. The conclusions are that many patients with BFS exhibit a significant decrease in SGNFD or ENFD, with the SGNFD preferentially affected. Small fiber neuropathy should be investigated as a potential cause or contributing factor to BFS.

Source: http://www.neurology.org/cgi/content/me ... ts/P01.139

Muscle cramps (and/or twitching) are a common complaint and are thought to arise from spontaneous discharges of the motor nerve terminal. Polyneuropathy is often causative, but small-fiber neuropathy (SFN) has not been assessed. We performed skin biopsies on consecutive patients with cramps but without neuropathic complaints. Twelve patients were biopsied, 8 with normal small-fiber sensation. Seven patients had decreased intraepidermal nerve fiber density (IENFD), 2 with non-length-dependent loss. A cause for neuropathy was found in 1 patient with cramp-fasciculation syndrome. Creatine kinase was elevated in 8 patients, 4 with decreased IENFD. Muscle biopsy, performed in 8 patients, but was diagnostic in only 1, with McArdle disease. Our data show that 60% of patients with muscle cramps who lack neuropathic complaints have SFN, as documented by decreased IENFD. Cramps may originate as local mediators of inflammation released by damaged small nerve that excite intramuscular nerves.

Source: http://www.pubfacts.com/detail/23813593 ... neuropathy

Re: BFS as a Manifestation of Small Fiber Neuropathy

PostPosted: August 10th, 2015, 6:04 am
by Xina535
another very helpful link! Thanks again! I do believe some people on here were diagnosed with SFN. The only way to be tested for that is a muscle/nerve/skin biopsy, right?

Re: BFS as a Manifestation of Small Fiber Neuropathy

PostPosted: August 10th, 2015, 2:05 pm
by misterjuanperalta
Based on the aforementioned, that's one way.