Hi MUPPETdog not sure if it was myself you seemed a bit perplexed with,
So the first statement I made was that CFS/ME was often associated with neuroinflammation and as this has been studied since 1969 there are numerous articles (literally in the 100s especially in the 1990s when interest in CFS/ME and then later gulf war syndrome really took off). These are from a huge range of disciplines especially from the fields of neurology, endocrinology, and immunology, also from conventional and alternative medical sources, and from the ancient histories of such syndromes.
There are also countless reviews throughout the last 2 decades which summarise the topic. Two good review articles about neuroinflammation and CFS/ME summarising the most recent developments (2013 and 2014), are the two listed below ( the second one gives a possible model which fits alot of what has been observed with inflammation in CFS). Though I am sure you will be able to find many more. The evidence is not simply a large number of small instances which begin to suggest a trend, but there are many large studies included throughout the years.
The third article is the one I referred to in my second statement i.e. concerning the areas of the brain involved in certain cases of CFS/ME. It is just out last month so is ahead of print, but you can get it on pubmed. This is a small study and I did say in my post it was just “one study”, but does use an interesting way to look at neuroinflammation, out with the usual markers.
I am sure you are more informed than myself about these things, hence why you started the discussion. Neurology not being my field, but I thought from a layman’s term (as I am) your post was interesting considering I had been to a seminar on this topic quite recently and some of the papers were discussed. I never thought of all these entities in the same way as Shawn did. The only reason I went to the seminar is that I am interested in TLRs in immunology, and they are often looked at in CFS/ME, so this novel way of assessing neuroinflammation interested me, as did your initial observation.
However here are the references. followed by their links. I know you yourself have used pubmed articles in your past posts so will know how to access them.
Hx
Curr Neuropharmacol. 2014 Mar;12(2):168-85. doi: 10.2174/1570159X11666131120224653.
Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).
Morris G1, Maes M2.
Metab Brain Dis. 2013 Dec;28(4):523-40. doi: 10.1007/s11011-012-9324-8. Epub 2012 Jun 21.
A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome.
Morris G1, Maes M
J Nucl Med. 2014 Mar 24. [Epub ahead of print]
Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study.
Nakatomi Y1, Watanabe Y.
Here are the pubmed links. to the abstracts and portal for access to full articles.
http://www.ncbi.nlm.nih.gov/pubmed/22718491A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome
http://www.ncbi.nlm.nih.gov/pubmed/24669210Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).
http://www.ncbi.nlm.nih.gov/pubmed/24665088Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study.