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More on VGKC Antibodies and Testing

Postby Angie on February 8th, 2008, 1:23 pm

I believe that Dr. Tahmoush told me that J Newsom-Davis was the person who discovered VGKC antibodies and their connection BCFS in autoimmune cases. Here's an article Newsom-Davis wrote that discusses a little more about it and his belief it was important to test for them (hint hint anyone going to a neurologist soon):


Acta Neurol Belg (2005) 105: 181-6.

Neuromuscular junction channelopathies: a brief overview.

J Newsom-Davis
University of Oxford, Department of Clinical Neurology, Oxford, UK.


...Neuromyotonia (NMT) and Cramp-Fasciculation syndrome (C-FS) are manifestations of peripheral nerve hyperexcitability and share some clinical and electromyographic features. Antibodies to voltage-gated potassium channels (VGKCs) are present in about 40% of NMT patients, but less frequently in C-FS, and appear to cause loss of functional VGKCs. ....The antibodies described here provide valuable aids to diagnosis and management. ..
Cramp-fasciculation syndrome: a treatable hyperexcitable peripheral nerve disorder.
Neurology. 1991 Jul;41(7):1021-4 Tahmoush AJ, et al.
"muscle aching, cramps, stiffness, exercise intolerance, and peripheral nerve hyper excitability"
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