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another email

PostPosted: August 29th, 2003, 12:50 am
by Brian_B
well my neurologist friend with BFS I have, emailed this, I had asked him what HE thought caused BFS



I don't know. I suspect that there may be more than
one cause. We know that certain medications like
physostigmin cause twitches by enhancing the
acetylcholine receptors at the nerve-muscle junction.
That fits with the autoimmune idea that some kind of
inflammatory process at the nerve-muscle synapses may
cause BFS. Other drugs may act further back on the
nerve at the motor neuron (also low potassium,
calcium, magnesium, statin drugs for treating
cholesterol.) There may be some energy alteration in
the neuron cell body that changes the resting
electrical voltage gradient of the cell membraine.
That can cause fasciculations because I did that in a
medical school lab project. Of course in ALS the cause
is a gene coded degeneration of the metabolism of the
cell so that it cannot maintain its sodium pump and
voltage graded calcium channels, so it fires
spontaneously. Pinched peripheral nerves at the elbow,
knee, and wrist often cause localised fasciculations
due to a wearing off of the myelin insulation on the
nerves. Then signals from one nerve jump to another
fiber or group of fibers. That occurs in Carpal tunnel
syndrome, and many different nerve injuries anywhere
along the course of the nerve. The signals causing the
fasciculations are called Ephaptic Transmission (i.e.
between demyelinated fibers). Of course these remain
localised to the muscles supplied by one nerve.

In short BFS may be at the level of the nerve cell
body, along the nerve axon, or at the end of the nerve
at the nerve-muscle synapes.

Domhnall