How OTC Deficiency compares to Ammonia-induced ALS

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How OTC Deficiency compares to Ammonia-induced ALS

Postby misterjuanperalta on December 27th, 2017, 8:25 pm

Aggravants / Precursors to OTC Deficiency -

Fructose - Fructose consumption leads to the accumulation of fructose-1-phosphate in cells, which may partially deplete intracellular ATP levels in susceptible individuals. Decreased cellular ATP causes disturbances in protein synthesis and reduced ammonia detoxification. Side-effects include fatigue, headaches, dizziness, behavioral changes and depressed immune function (autoimmunity, allergies).

Source: http://www.drkaslow.com/html/fructose.html

Low stomach acid - Low stomach acid impairs the proper digestion of foods, including protein, and elevates ammonia levels. Treatment could include ingesting vinegar before and after meals. Because vinegar is an acid and ammonia is a base, ingesting it neutralizes and detoxifies ammonia, producing salt and water as a byproduct. In fact, Lactulose, used to treat hyperammonemia, is metabolized in the colon to form short-chain fatty acids, including lactic acid and acetic acid. Acetic acid makes up about 5–6% of apple cider vinegar.

Source: http://www.wakingtimes.com/2015/04/16/p ... dic-foods/, https://en.wikipedia.org/wiki/Lactulose, https://articles.mercola.com/sites/arti ... -hype.aspx

• • • • • • • • • • • • • • • • • • • • • • •

OTC Deficiency Findings:

• Episodes of hyperammonemia secondary to increased protein intake.

https://emedicine.medscape.com/article/ ... -treatment

• Emphasis on low protein diet

https://www.ncbi.nlm.nih.gov/pubmed/25949836

• Decreased arginine

https://www.ncbi.nlm.nih.gov/pubmed/28597413

• Elevated glutamine

https://www.ncbi.nlm.nih.gov/pubmed/28266016
https://www.ncbi.nlm.nih.gov/pubmed/25958381

• • • • • • • • • • • • • • • • • • • • • • •

Ammonia-induced ALS Findings:

• Dietary protein can cause chronic hyperammonemia, neurodegeneration and motor impairments.

• Decreased arginine levels found in ALS patients.

• Elevated glutamine, a precursor of ammonia, found in familial ALS.

• Intense or prolonged physical exertion, an ammoniogenic activity, is an ALS risk factor that explains the sudden onset of symptoms. Ammonia-removal strategies seem to be the most effective strategy for ALS treatment.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063041/
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How OTC Deficiency compares to Ammonia-induced ALS

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